Intralesional rose bengal (PV‐10, 10% RB in saline) can elicit selective chemoablation of solid tumors and an apparent bystander response in untreated lesions. In phase I (20 subjects with AJCC stage III‐IV melanoma), a single injection into a total of 114 lesions was well tolerated, yielding durable objective response (OR) at 12‐24 weeks in 40% of subjects (20% CR + 20% PR by modified RECIST) and locoregional disease control (CR+PR+SD) in 75% of subjects; 15% of subjects achieved an OR in their bystander lesions (43 lesions).
read more : Chemoablation of metastatic melanoma with Rose Bengal (PV-10) (Agarwala S.S, Thompson J.F e coll
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