A study published on Cancer Research announces that sentinel node act as pivotal sites for determining progression patterns, revealing that the presence of CD30+ lymphocytes at those sites associate positively with melanoma progression. Read the abstract ! Vallacchi V, Vergani E, Camisaschi C, et al. Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome
Breslow thickness ≥ 0.75 mm, Clark level ≥ IV, and ulceration significantly predict SLN disease in thin melanoma. Most SLN metastases (86.2%) occur in melanomas ≥ 0.75 mm, with 6.3% of these patients having SLN disease, whereas in melanomas < 0.75 mm, SLN metastasis rates are < 5%. By using a 5% metastasis risk threshold,
Abstract from PLOS ONE: Intralesional Injection of Rose Bengal Induces a Systemic Tumor-Specific Immune Response in Murine Models of Melanoma and Breast Cancer Paul Toomey, Krithika Kodumudi, Amy Weber, Lisa Kuhn, Ellen Moore, Amod A. Sarnaik, Shari Pilon-Thomas Intralesional (IL) injection of PV-10 has shown to induce regression of both injected and non-injected lesions in patients with melanoma. To determine
A new articles on melanoma pubblished in Los Angeles Times: My melanoma, my message: As a surgical oncologist, I’m usually the one delivering the bad news. But this time I was the recipient.Nine days earlier, my dermatologist had taken a biopsy from a small pink dot on my back, and now the results were available.
GlaxoSmithKline plc [announced today that the U.S. Food and Drug Administration (FDA) has approved both TAFINLAR® (dabrafenib) and MEKINIST™ (trametinib). Tafinlar is indicated as a single-agent oral treatment for unresectable melanoma (melanoma that cannot be removed by surgery) or metastatic melanoma (melanoma which has spread to other parts of the body) in adult patients with BRAF
Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In
The U.S. Environmental Protection Agency (EPA), along with the National Council on Skin Cancer Prevention, the Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC), is calling the Friday before Memorial Day “Don’t Fry Day” hoping to motivate people to stay safe outdoors. Janet McCabe, deputy assistant administrator for EPA’s
A new study conducted using extensive medical records of over one million Israeli adolescents before military service shows clearly how exposure to the Israeli sun of young, light-skinned children increases substantially the risk of cutaneous melanoma (a serious form of skin cancer). The incidence of cutaneous melanoma is on the rise in all parts of