{"id":10122,"date":"2023-06-23T07:24:52","date_gmt":"2023-06-23T06:24:52","guid":{"rendered":"https:\/\/www.ilmelanoma.com\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/"},"modified":"2026-10-17T10:07:14","modified_gmt":"2026-10-17T09:07:14","slug":"myxoid-melanoma","status":"publish","type":"page","link":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/","title":{"rendered":"Myxoid melanoma"},"content":{"rendered":"<div class=\"im26-diagnosis-guide\">\n<nav class=\"im26-dg-toc\" aria-label=\"On this page\"><strong>On this page<\/strong><\/p>\n<ol>\n<li><a href=\"#rf-definizione\">What myxoid means<\/a><\/li>\n<li><a href=\"#rf-presentazione\">Clinical appearance and pigmentation<\/a><\/li>\n<li><a href=\"#rf-istologia\">Matrix, stains and markers<\/a><\/li>\n<li><a href=\"#rf-gestione\">Management and evidence limitations<\/a><\/li>\n<\/ol>\n<\/nav>\n<section class=\"im26-dg-section\" id=\"rf-definizione\">\n<h2>What myxoid means<\/h2>\n<p>Myxoid melanoma is a rare histological presentation in which tumour cells lie within an extracellular matrix rich in mucinous substances such as glycosaminoglycans. \u201cMyxoid\u201d describes the tissue environment rather than mucus visibly produced on the skin.<\/p>\n<p>A myxoid component has been described in metastases and primary melanomas, including noncutaneous sites such as sinonasal regions. The name alone therefore does not establish origin. A pale or gelatinous-looking microscopic matrix does not necessarily produce a visibly cystic or translucent lesion.<\/p>\n<\/section>\n<section class=\"im26-dg-section\" id=\"rf-presentazione\">\n<h2>Clinical appearance and pigmentation<\/h2>\n<p>It may appear as a mass or nodule, sometimes enlarging, with little or no pigment. Reported trunk and limb locations are not exclusive. An amelanotic appearance can make clinical recognition more difficult, as it can in other melanoma types.<\/p>\n<p>No external sign identifies it with certainty. A previous melanoma history matters when a new lesion appears but does not alone establish metastasis. Diagnosis requires adequate tissue.<\/p>\n<\/section>\n<section class=\"im26-dg-section\" id=\"rf-istologia\">\n<h2>Matrix, stains and markers<\/h2>\n<p>Histology may show malignant cells of varying size and shape within myxoid stroma. Stains for mucinous substances, such as Alcian blue, can demonstrate the matrix. Mucicarmine and diastase-PAS contribute to differential diagnosis according to the sample. Results described in individual cases should not become a mandatory sequence of positive and negative stains.<\/p>\n<p>The matrix\u2019s origin and composition have received different interpretations; it is not established that every case reflects only a tissue response and never tumour-cell production. The appearance must be distinguished from other myxoid neoplasms, including mesenchymal and other cellular lineages.<\/p>\n<p>S100, SOX10 and melanocytic markers may form part of the panel, with variable expression. E9 staining mentioned in historical descriptions is not a standard clinical test independently predicting rapid progression. Architecture, <a href=\"https:\/\/www.ilmelanoma.com\/en\/melanoma\/istopatologia-del-melanoma\/\">immunohistochemistry<\/a>, clinical findings and earlier samples must be integrated.<\/p>\n<div class=\"im26-dg-gallery\">\n<figure><a href=\"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg\" aria-label=\"Open original image\"><img loading=\"lazy\" src=\"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg\" width=\"1083\" height=\"722\" loading=\"lazy\" decoding=\"async\" alt=\"Myxoid melanoma: archive image\"\/><\/a><figcaption>Clinical or histological image retained from the site archive. It cannot be used for self-diagnosis.<\/figcaption><\/figure>\n<\/div>\n<\/section>\n<section class=\"im26-dg-section\" id=\"rf-gestione\">\n<h2>Management and evidence limitations<\/h2>\n<p>There is no established treatment regimen specific to the myxoid component alone. Management follows the primary site, stage, operability and biology: <a href=\"https:\/\/www.ilmelanoma.com\/en\/guides\/treatment\/\">surgery<\/a> where appropriate, systemic options when indicated and radiotherapy in selected situations.<\/p>\n<p>Chemotherapy should not automatically become the first option merely because the variant is rare. In difficult cases, pathology review may prevent resemblance to a sarcoma from leading to an inappropriate pathway.<\/p>\n<p>Prognosis and follow-up depend on the disease as a whole. Ask whether the sample represents a primary lesion or metastasis and which conclusions are established rather than based on limited literature.<\/p>\n<\/section>\n<aside class=\"im26-dg-related\">\n<h2>Continue reading<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/\">Rare variants of melanoma<\/a><\/li>\n<li><a href=\"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/signet-ring-melanoma\/\">Signet ring cell melanoma<\/a><\/li>\n<li><a href=\"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/rhabdoid-melanoma\/\">Rhabdoid melanoma<\/a><\/li>\n<li><a href=\"https:\/\/www.ilmelanoma.com\/en\/guides\/diagnosis\/\">The diagnostic pathway<\/a><\/li>\n<li><a href=\"https:\/\/www.ilmelanoma.com\/en\/guides\/treatment\/\">Understanding treatment<\/a><\/li>\n<\/ul>\n<\/aside>\n<section class=\"im26-dg-sources\">\n<h2>Sources and update<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.cancer.gov\/types\/skin\/hp\/melanoma-treatment-pdq\">NCI \u2014 Melanoma Treatment (PDQ)<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.pathol.2022.11.006\">Lowe \u2014 Metastatic melanoma and rare melanoma variants (2023)<\/a><\/li>\n<\/ul>\n<p>Editorial revision: 17 October 2026. This information does not replace medical assessment. For very rare variants, some evidence comes from small series or case reports.<\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The meaning of a myxoid matrix in melanoma: tissue features, differential diagnosis and clinical decisions.<\/p>\n","protected":false},"author":13,"featured_media":10120,"parent":10105,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10122","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Myxoid melanoma - Il Melanoma<\/title>\n<meta name=\"description\" content=\"Myxoid melanoma often manifests as myxoid deposits in melanoma metastases, primary myxoid melanomas of the skin have also been described\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Myxoid melanoma - Il Melanoma\" \/>\n<meta property=\"og:description\" content=\"Myxoid melanoma often manifests as myxoid deposits in melanoma metastases, primary myxoid melanomas of the skin have also been described\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/\" \/>\n<meta property=\"og:site_name\" content=\"Il Melanoma\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-17T09:07:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/\",\"url\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/\",\"name\":\"Myxoid melanoma - Il Melanoma\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ilmelanoma.com\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/Melanoma-mixoide.jpg\",\"datePublished\":\"2023-06-23T06:24:52+00:00\",\"dateModified\":\"2026-10-17T09:07:14+00:00\",\"description\":\"Myxoid melanoma often manifests as myxoid deposits in melanoma metastases, primary myxoid melanomas of the skin have also been described\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.ilmelanoma.com\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/Melanoma-mixoide.jpg\",\"contentUrl\":\"https:\\\/\\\/www.ilmelanoma.com\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/Melanoma-mixoide.jpg\",\"width\":1083,\"height\":722},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/myxoid-melanoma\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Melanoma\",\"item\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Rare variants of melanoma\",\"item\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/melanoma\\\/rare-variants-of-melanoma\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Myxoid melanoma\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/\",\"name\":\"Il Melanoma\",\"description\":\"la guida alla conoscenza, prevenzione e cura del melanoma\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/#organization\",\"name\":\"Il Melanoma\",\"alternateName\":\"ilmelanoma.com\",\"url\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ilmelanoma.com\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/logo-melanoma-azzurro.png\",\"contentUrl\":\"https:\\\/\\\/www.ilmelanoma.com\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/logo-melanoma-azzurro.png\",\"width\":300,\"height\":29,\"caption\":\"Il Melanoma\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ilmelanoma.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Myxoid melanoma - Il Melanoma","description":"Myxoid melanoma often manifests as myxoid deposits in melanoma metastases, primary myxoid melanomas of the skin have also been described","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/","og_locale":"en_US","og_type":"article","og_title":"Myxoid melanoma - Il Melanoma","og_description":"Myxoid melanoma often manifests as myxoid deposits in melanoma metastases, primary myxoid melanomas of the skin have also been described","og_url":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/","og_site_name":"Il Melanoma","article_modified_time":"2026-10-17T09:07:14+00:00","og_image":[{"url":"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/","url":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/","name":"Myxoid melanoma - Il Melanoma","isPartOf":{"@id":"https:\/\/www.ilmelanoma.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/#primaryimage"},"image":{"@id":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg","datePublished":"2023-06-23T06:24:52+00:00","dateModified":"2026-10-17T09:07:14+00:00","description":"Myxoid melanoma often manifests as myxoid deposits in melanoma metastases, primary myxoid melanomas of the skin have also been described","breadcrumb":{"@id":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/#primaryimage","url":"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg","contentUrl":"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/Melanoma-mixoide.jpg","width":1083,"height":722},{"@type":"BreadcrumbList","@id":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/myxoid-melanoma\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Melanoma","item":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/"},{"@type":"ListItem","position":2,"name":"Rare variants of melanoma","item":"https:\/\/www.ilmelanoma.com\/en\/melanoma\/rare-variants-of-melanoma\/"},{"@type":"ListItem","position":3,"name":"Myxoid melanoma"}]},{"@type":"WebSite","@id":"https:\/\/www.ilmelanoma.com\/en\/#website","url":"https:\/\/www.ilmelanoma.com\/en\/","name":"Il Melanoma","description":"la guida alla conoscenza, prevenzione e cura del melanoma","publisher":{"@id":"https:\/\/www.ilmelanoma.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ilmelanoma.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.ilmelanoma.com\/en\/#organization","name":"Il Melanoma","alternateName":"ilmelanoma.com","url":"https:\/\/www.ilmelanoma.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.ilmelanoma.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/logo-melanoma-azzurro.png","contentUrl":"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2023\/06\/logo-melanoma-azzurro.png","width":300,"height":29,"caption":"Il Melanoma"},"image":{"@id":"https:\/\/www.ilmelanoma.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/pages\/10122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/comments?post=10122"}],"version-history":[{"count":2,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/pages\/10122\/revisions"}],"predecessor-version":[{"id":11068,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/pages\/10122\/revisions\/11068"}],"up":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/pages\/10105"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/media\/10120"}],"wp:attachment":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/media?parent=10122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}