{"id":6961,"date":"2012-01-28T17:46:43","date_gmt":"2012-01-28T16:46:43","guid":{"rendered":"http:\/\/www.ilmelanoma.com\/?p=6961"},"modified":"2026-10-16T10:47:09","modified_gmt":"2026-10-16T09:47:09","slug":"zelboraf-therapy-of-metastatic-melanoma-accelerates-cutaneous-squamous-cell-carcinomas-and-keratoacanthomas-2","status":"publish","type":"post","link":"https:\/\/www.ilmelanoma.com\/en\/zelboraf-therapy-of-metastatic-melanoma-accelerates-cutaneous-squamous-cell-carcinomas-and-keratoacanthomas-2\/","title":{"rendered":"Zelboraf therapy of metastatic melanoma accelerates cutaneous squamous-cell carcinomas and keratoacanthomas"},"content":{"rendered":"<div>\n<p>One study published in the New England Journal of Medicine Mutations \u00a0reports that mutation in\u00a0RAS,\u00a0particularly\u00a0HRAS,\u00a0are frequent in cutaneous squamous-cell carcinomas and keratoacanthomas that develop in patients treated with vemurafenib. The molecular mechanism is consistent with the paradoxical activation of MAPK signaling and leads to accelerated growth of these lesions<\/p>\n<p>read more:\u00a0<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1105358\" target=\"_blank\">RAS\u00a0Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>One study published in the New England Journal of Medicine Mutations \u00a0reports that mutation in\u00a0RAS,\u00a0particularly\u00a0HRAS,\u00a0are frequent in cutaneous squamous-cell carcinomas and keratoacanthomas that develop in patients treated with vemurafenib. The molecular mechanism is consistent with the paradoxical activation of MAPK signaling and leads to accelerated growth of these lesions read more:\u00a0RAS\u00a0Mutations in Cutaneous Squamous-Cell Carcinomas [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-6961","post","type-post","status-publish","format-standard","hentry","category-cura-melanoma"],"_links":{"self":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/6961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/comments?post=6961"}],"version-history":[{"count":1,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/6961\/revisions"}],"predecessor-version":[{"id":10821,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/6961\/revisions\/10821"}],"wp:attachment":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/media?parent=6961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/categories?post=6961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/tags?post=6961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}