{"id":7099,"date":"2012-03-31T22:28:48","date_gmt":"2012-03-31T21:28:48","guid":{"rendered":"http:\/\/www.ilmelanoma.com\/?p=7099"},"modified":"2026-10-16T10:46:54","modified_gmt":"2026-10-16T09:46:54","slug":"intralesional-therapy-with-rosa-bengal-pv-10-in-metastatic-melanoma","status":"publish","type":"post","link":"https:\/\/www.ilmelanoma.com\/en\/intralesional-therapy-with-rosa-bengal-pv-10-in-metastatic-melanoma\/","title":{"rendered":"Intralesional therapy with Rosa Bengal (PV-10) in metastatic melanoma"},"content":{"rendered":"<div>\n<div>\n<div>\n<div>\n<p>Intralesional rose bengal (PV\u201010, 10% RB in saline) can elicit selective chemoablation of\u00a0solid tumors and an apparent bystander response in untreated lesions. In phase I (20 subjects with AJCC stage III\u2010IV melanoma), a single injection into a total of 114 lesions was well tolerated, yielding durable objective response (OR) at 12\u201024 weeks in 40% of subjects (20% CR + 20% PR by modified RECIST) and locoregional disease control (CR+PR+SD) in 75% of subjects; 15% of subjects achieved an OR in their bystander lesions (43 lesions).<\/p>\n<\/div>\n<div>\n<p>read more : <a href=\"https:\/\/www.pvct.com\/publications\/ASCO_Poster-2010.pdf\" target=\"_blank\">Chemoablation of metastatic melanoma with Rose Bengal (PV-10) (Agarwala S.S, Thompson J.F e coll<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div>\n<div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Intralesional rose bengal (PV\u201010, 10% RB in saline) can elicit selective chemoablation of\u00a0solid tumors and an apparent bystander response in untreated lesions. In phase I (20 subjects with AJCC stage III\u2010IV melanoma), a single injection into a total of 114 lesions was well tolerated, yielding durable objective response (OR) at 12\u201024 weeks in 40% of [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-7099","post","type-post","status-publish","format-standard","hentry","category-cura-melanoma"],"_links":{"self":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/7099","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/comments?post=7099"}],"version-history":[{"count":1,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/7099\/revisions"}],"predecessor-version":[{"id":10800,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/7099\/revisions\/10800"}],"wp:attachment":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/media?parent=7099"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/categories?post=7099"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/tags?post=7099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}