{"id":7165,"date":"2012-04-29T11:15:19","date_gmt":"2012-04-29T10:15:19","guid":{"rendered":"http:\/\/www.ilmelanoma.com\/?p=7165"},"modified":"2026-10-16T10:46:50","modified_gmt":"2026-10-16T09:46:50","slug":"discovered-cloaking-protein-that-hides-melanomas-cells-from-immune-system","status":"publish","type":"post","link":"https:\/\/www.ilmelanoma.com\/en\/discovered-cloaking-protein-that-hides-melanomas-cells-from-immune-system\/","title":{"rendered":"Discovered cloaking protein that hides melanomas cells from immune system"},"content":{"rendered":"<p style=\"text-align: justify;\">Johns Hopkins and Yale scientists have found that melanoma cells use a cloaking protein to hide from immune cells poised to attack the cancer.\u00a0 Nearly 40 percent of their sampling of melanoma tissues contained the B7-H1 protein, also called PD-L1, and scientists say it could be used as a target for new therapies.\u00a0For the study, described in the March 28 issue of\u00a0<a title=\"Science Translational Medicine\" accesskey=\"\" href=\"https:\/\/stm.sciencemag.org\/\" rel=\"\" target=\"_blank\"><em>Science Translational Medicine<\/em><\/a>, the research team analyzed 150 samples of benign melanocytic lesions, and primary and metastatic melanomas, looking for expression of B7-H1 above a threshold of five percent.\u00a0 Of the samples, collected from patients at Johns Hopkins, 57 (38 percent) were positive for the B7-H1 cloaking protein. \u00a0Previous research by Yale scientist and B7-H1 discoverer Leiping Chen, Ph.D., formerly of Johns Hopkins, established that some melanoma cells express B7-H1, which renders the cells invisible to T-cells.\u00a0 These t-cells release interferon gamma, a potent signal to trigger cancer cell-killing.\u00a0 But it turns out that interferon gamma also prompts melanoma cells to make more B7-H1, further cloaking the melanoma cells from the immune system.<\/p>\n<p style=\"text-align: justify;\">Read more. Johns Hopkins (medicine): <a href=\"https:\/\/www.hopkinsmedicine.org\/news\/media\/releases\/some_melanomas_use_cloaking_protein_to_hide_from_immune_cells\">Some melanomas use cloaking protein to hide immune cells<\/a><\/p>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Johns Hopkins and Yale scientists have found that melanoma cells use a cloaking protein to hide from immune cells poised to attack the cancer.\u00a0 Nearly 40 percent of their sampling of melanoma tissues contained the B7-H1 protein, also called PD-L1, and scientists say it could be used as a target for new therapies.\u00a0For the study, [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[952],"tags":[],"class_list":["post-7165","post","type-post","status-publish","format-standard","hentry","category-ricerca"],"_links":{"self":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/7165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/comments?post=7165"}],"version-history":[{"count":1,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/7165\/revisions"}],"predecessor-version":[{"id":10795,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/posts\/7165\/revisions\/10795"}],"wp:attachment":[{"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/media?parent=7165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/categories?post=7165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ilmelanoma.com\/en\/wp-json\/wp\/v2\/tags?post=7165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}