{"id":8483,"date":"2013-09-03T06:19:49","date_gmt":"2013-09-03T06:19:49","guid":{"rendered":"http:\/\/www.ilmelanoma.com\/?p=8483"},"modified":"2013-09-03T06:19:49","modified_gmt":"2013-09-03T06:19:49","slug":"human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells","status":"publish","type":"post","link":"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/","title":{"rendered":"Human skin carcinoma arising from kidney transplant\u2013derived tumor cells"},"content":{"rendered":"<p style=\"text-align: justify;\">Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and <i>TP53<\/i> mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor\/recipient origin in laser-microdissected p53<sup>+<\/sup> tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a <i>TP53<\/i> mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53<sup>+<\/sup> cells in the renal tubules. We identified the same <i>TP53<\/i> mutation in these p53<sup>+<\/sup> epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation.This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":9685,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[209,211],"tags":[],"class_list":["post-8483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-spotlight"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Human skin carcinoma arising from kidney transplant\u2013derived tumor cells<\/title>\n<meta name=\"description\" content=\"Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor\/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53+ cells in the renal tubules\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dott.ssa Matilde Angelotti\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/\"},\"author\":{\"name\":\"Dott.ssa Matilde Angelotti\",\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/#\/schema\/person\/0587ef084351b31b95f697a5f7762f32\"},\"headline\":\"Human skin carcinoma arising from kidney transplant\u2013derived tumor cells\",\"datePublished\":\"2013-09-03T06:19:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/\"},\"wordCount\":192,\"publisher\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2012\/12\/sun-spf-30.jpg\",\"articleSection\":[\"News\",\"Spotlight\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/\",\"url\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/\",\"name\":\"Human skin carcinoma arising from kidney transplant\u2013derived tumor cells\",\"isPartOf\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/human-skin-carcinoma-arising-kidney-transplantderived-tumor-cells\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2012\/12\/sun-spf-30.jpg\",\"datePublished\":\"2013-09-03T06:19:49+00:00\",\"description\":\"Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor\/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. 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