{"id":8881,"date":"2014-01-18T09:19:43","date_gmt":"2014-01-18T08:19:43","guid":{"rendered":"http:\/\/www.ilmelanoma.com\/?p=8881"},"modified":"2014-01-18T09:19:43","modified_gmt":"2014-01-18T08:19:43","slug":"sentinel-node-biopsy-can-predict-melanoma-progression","status":"publish","type":"post","link":"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/","title":{"rendered":"Sentinel node biopsy can predict melanoma progression"},"content":{"rendered":"<p style=\"text-align: justify;\">A study published on Cancer Research announces that sentinel node act as pivotal sites for determining progression patterns, revealing that the presence of CD30<sup>+<\/sup>\u00a0lymphocytes at those sites associate positively with melanoma progression. Read the abstract !<\/p>\n<p style=\"text-align: justify;\"><em style=\"line-height: 1.5em;\"><a title=\"Linfonodo sentinella\" href=\"https:\/\/cancerres.aacrjournals.org\/content\/74\/1\/130.abstract\" target=\"_blank\">Vallacchi V, Vergani E, Camisaschi C, et al. Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression. Cancer Res; 74(1); 130\u201340<\/a><\/em><\/p>\n<p style=\"text-align: justify;\">Sentinel lymph nodes set the stance of the immune system to a localized tumor and are often the first site to be colonized by neoplastic cells that metastasize. To investigate how the presence of neoplastic cells in sentinel lymph nodes may trigger pathways associated with metastatic progression, we analyzed the transcriptional profiles of archival sentinel node biopsy specimens obtained from melanoma patients. Biopsies from positive nodes were selected for comparable tumor infiltration, presence or absence of further regional node metastases, and relapse at 5-year follow-up. Unsupervised analysis of gene expression profiles revealed immune response to be a major gene ontogeny represented. Among genes upregulated in patients with progressing disease, the TNF receptor family member CD30\/TNFRSF8\u00a0was confirmed in biopsy specimens from an independent group of patients. Immunohistochemical analysis revealed higher numbers of CD30<sup>+<\/sup>\u00a0lymphocytes in nodes from progressing patients compared with nonprogressing patients. Phenotypic profiling demonstrated that CD30<sup>+<\/sup>\u00a0lymphocytes comprised a broad population of suppressive or exhausted immune cells, such as CD4<sup>+<\/sup>Foxp3<sup>+<\/sup>\u00a0or PD1<sup>+<\/sup>\u00a0subpopulations and CD4<sup>\u2212<\/sup>CD8<sup>\u2212<\/sup>\u00a0T cells. CD30<sup>+<\/sup>\u00a0T lymphocytes were increased in peripheral blood lymphocytes of melanoma patients at advanced disease stages. Our findings reinforce the concept that sentinel nodes act as pivotal sites for determining progression patterns, revealing that the presence of CD30<sup>+<\/sup>\u00a0lymphocytes at those sites associate positively with melanoma progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study published on Cancer Research announces that sentinel node act as pivotal sites for determining progression patterns, revealing that the presence of CD30+\u00a0lymphocytes at those sites associate positively with melanoma progression. Read the abstract ! Vallacchi V, Vergani E, Camisaschi C, et al. Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":7231,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[209,211],"tags":[711,328,710,709],"class_list":["post-8881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-spotlight","tag-disease-progression","tag-melanoma-en","tag-sentinel-node","tag-sentinel-node-biopsy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sentinel node biopsy can predict melanoma progression - Il Melanoma<\/title>\n<meta name=\"description\" content=\"that sentinel nodes act as pivotal sites for determining progression patterns, revealing that the presence of CD30+ lymphocytes at those sites associate positively with melanoma progression.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dott.ssa Matilde Angelotti\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/\"},\"author\":{\"name\":\"Dott.ssa Matilde Angelotti\",\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/#\/schema\/person\/0587ef084351b31b95f697a5f7762f32\"},\"headline\":\"Sentinel node biopsy can predict melanoma progression\",\"datePublished\":\"2014-01-18T08:19:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/\"},\"wordCount\":293,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.ilmelanoma.com\/wp-content\/uploads\/2012\/06\/molecola.jpg\",\"keywords\":[\"disease progression\",\"melanoma\",\"sentinel node\",\"sentinel node biopsy\"],\"articleSection\":[\"News\",\"Spotlight\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/\",\"url\":\"https:\/\/www.ilmelanoma.com\/en\/sentinel-node-biopsy-can-predict-melanoma-progression\/\",\"name\":\"Sentinel node biopsy can predict melanoma progression - 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