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Malignant melanoma is the most dangerous of skin cancers and it’s a cancer that originates from melanocytes, cells responsible for the production of melanin.

The reading of the various pages of the website will help you to understand the various aspects of melanoma, while in the “Resources on melanoma” you will find information on the links, books, conferences and other useful information.

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Higher coffee intake and decrease melanoma risk

Higher coffee intake and decrease melanoma risk

A study published by Oxford University press reveals that higher coffee intake was associated with a modest decrease in risk of melanoma;  the highest category of coffee intake was inversely associated with malignant melanoma. This association was statistically significant for caffeinated but not for decaffeinated coffee Coffee Drinking and Cutaneous Melanoma Risk in the NIH-AARP

A new treatment of metastatic melanoma: combined therapy with cobimetinib and vemurafenib

A new treatment of metastatic melanoma: combined therapy with cobimetinib and vemurafenib

This phase 3 study showed an improvement in the response rate and in progression-free survival when cobimetinib was added to vemurafenib. Together with the results of a phase 3 trial comparing dabrafenib plus trametinib with dabrafenib alone,19 these findings provide clear evidence of the benefit of combined MEK and BRAF inhibition. The data combining BRAF

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent protein kinase A (PKA)-dependent manner. PKA directly phosphorylates ataxia telangiectasia and Rad3-related protein (ATR) at Ser435, which actively

Sentinel node biopsy can predict melanoma progression

Sentinel node biopsy can predict melanoma progression

A study published on Cancer Research announces that sentinel node act as pivotal sites for determining progression patterns, revealing that the presence of CD30+ lymphocytes at those sites associate positively with melanoma progression. Read the abstract ! Vallacchi V, Vergani E, Camisaschi C, et al. Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome