Melanoma

Malignant melanoma is the most dangerous of skin cancers and it’s a cancer that originates from melanocytes, cells responsible for the production of melanin.

The reading of the various pages of the website will help you to understand the various aspects of melanoma, while in the “Resources on melanoma” you will find information on the links, books, conferences and other useful information.

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Woman has to have ear amputated due to ‘self-inflicted’ melanoma caused by sunbeds

A 44-year-old woman has opened up about how she had to have her ear amputated following a ‘self-inflicted’ melanoma. Anthea Smith, from Bolton, developed a tanning addition at the age of 14, but was unaware of the serious dangers sunbeds can cause to skin. She first noticed a strange red spot on her outer ear

Bob Marley Shouldn’t Have Died from Melanoma

Bob Marley should be celebrating his 71st birthday today. Instead, the Jamaican singer, musician and songwriter died of melanoma in 1981 when he was only 36. It’s easy to see how he could have missed the warning signs. People with very fair skin are the ones most at risk for skin cancer. When a dark spot

Citrus fruits and melanoma risk

The researchers found that the more servings of oranges, grapefruits or juices from these fruits that the participants consumed overall, the higher their risk of melanoma. Subjects who consumed a serving of these fruits or their juices at least 1.6 times a day, for example, were found to be at 36% higher melanoma risk. It may

New therapy for metastatic melanoma

Results of a new study by UCLA researchers has found that a groundbreaking new triple combination therapy shows promising signs of more effectively controlling advanced melanoma than previous BRAF + MEK inhibitor or BRAF inhibitor + immunotherapy combos alone, and with increased immune response and fewer side effects. In the new study led by UCLA Jonsson

Higher coffee intake and decrease melanoma risk

A study published by Oxford University press reveals that higher coffee intake was associated with a modest decrease in risk of melanoma; the highest category of coffee intake was inversely associated with malignant melanoma. This association was statistically significant for caffeinated but not for decaffeinated coffee Coffee Drinking and Cutaneous Melanoma Risk in the NIH-AARP

Australia bans sunbeds

Most Australian states and territories are set to ban commercial sunbeds from Thursday, in a crackdown on artificial tanning in a country that has one of the highest rates of skin cancer in the world. The ban — which comes into force in the states of New South Wales, Victoria, South Australia, Tasmania, Queensland and in

A new treatment of metastatic melanoma: combined therapy with cobimetinib and vemurafenib

This phase 3 study showed an improvement in the response rate and in progression-free survival when cobimetinib was added to vemurafenib. Together with the results of a phase 3 trial comparing dabrafenib plus trametinib with dabrafenib alone,19 these findings provide clear evidence of the benefit of combined MEK and BRAF inhibition. The data combining BRAF

Association between moles and breast cancer

A study proposed by Mingfeng Zhang, Xuehong Zhang, Abrar A. Qureshi, A. Heather Eliassen, Susan E. Hankinson, Jiali Han, hypothesizes the number of cutaneous nevi may reflect plasma hormone levels and predict breast cancer risk independently of previously known factors. read: “In summary, we identified the number of cutaneous nevi as a novel phenotypic marker

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent protein kinase A (PKA)-dependent manner. PKA directly phosphorylates ataxia telangiectasia and Rad3-related protein (ATR) at Ser435, which actively

The importance of early detection of melanoma in children

Increasingly important is the control of nevi in children, the incidence of melanoma in children is on the rise; the causes are debated, it seems that the exposure of children to sunlight during the middle of the day can play an important role. Those with fair skin, blonde or red hair, freckles, the inability to