Identified a new oncogene, HINT1 that regulates MITF and β-catenin transcriptional activity in melanoma cells
Reserchers of University Sacro Cuore of Rome have identified a new molecule, absent in melanoma cells, that inhibits melanoma cell proliferation. Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells. MITF and β-catenin