Pazienti trapiantati di rene hanno un maggior rischio di sviluppare forme invasive di tumore cutaneo originate dalle cellule del donatore. L’articolo è uscito sul Journal of Clinical Investigation, Philippe Ratajczak and colleghi hannoesaminato tumori cutanei e tessuto trapiantato di alcuni pazienti trapiantti di rene che successivamente avevano sviluppato epiteliomi squamocellulari e hanno dimostrato che le cellule tumorali avevano le stesso genotipo di quelle del rene donato.
leggi anche: Human skin carcinoma arising from kidney transplant–derived tumor cells:Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53+ cells in the renal tubules. We identified the same TP53 mutation in these p53+ epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation. This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients