Differential diagnosis of melanoma

Lesions that may look alike

Possibilities include melanocytic and blue naevi, pigmented seborrhoeic keratoses, solar lentigines, vascular lesions, dermatofibromas, bleeding beneath the skin and other skin cancers such as pigmented basal cell carcinoma. This is not an exhaustive list.

How assessment works

The doctor considers onset, changes, symptoms and injuries, examines the lesion and may use dermoscopy. Histological examination is performed when necessary. A comparison table cannot replace this process.

Avoid misleading shortcuts

Do not assume a spot is harmless because it followed an injury, is blue or seems to fade with pressure. There is no universal rule that a bruise or injured mole must return to normal within ten days. Persistent or suspicious changes need assessment.

When to seek advice

Contact a doctor about a concerning new lesion, one unlike the others, one that changes or one that bleeds. If uncertainty remains, ask how it will be resolved and when the next steps will happen.

Sources and update

Editorial update: 16 October 2026. This information provides guidance and does not replace a medical assessment.