A 44-year-old woman has opened up about how she had to have her ear amputated following a ‘self-inflicted’ melanoma. Anthea Smith, from Bolton, developed a tanning addition at the age of 14, but was unaware of the serious dangers sunbeds can cause to skin. She first noticed a strange red spot on her outer ear
Bob Marley should be celebrating his 71st birthday today. Instead, the Jamaican singer, musician and songwriter died of melanoma in 1981 when he was only 36. It’s easy to see how he could have missed the warning signs. People with very fair skin are the ones most at risk for skin cancer. When a dark spot
The researchers found that the more servings of oranges, grapefruits or juices from these fruits that the participants consumed overall, the higher their risk of melanoma. Subjects who consumed a serving of these fruits or their juices at least 1.6 times a day, for example, were found to be at 36% higher melanoma risk. It may
Results of a new study by UCLA researchers has found that a groundbreaking new triple combination therapy shows promising signs of more effectively controlling advanced melanoma than previous BRAF + MEK inhibitor or BRAF inhibitor + immunotherapy combos alone, and with increased immune response and fewer side effects. In the new study led by UCLA Jonsson
A study published by Oxford University press reveals that higher coffee intake was associated with a modest decrease in risk of melanoma; the highest category of coffee intake was inversely associated with malignant melanoma. This association was statistically significant for caffeinated but not for decaffeinated coffee Coffee Drinking and Cutaneous Melanoma Risk in the NIH-AARP
Most Australian states and territories are set to ban commercial sunbeds from Thursday, in a crackdown on artificial tanning in a country that has one of the highest rates of skin cancer in the world. The ban — which comes into force in the states of New South Wales, Victoria, South Australia, Tasmania, Queensland and in
This phase 3 study showed an improvement in the response rate and in progression-free survival when cobimetinib was added to vemurafenib. Together with the results of a phase 3 trial comparing dabrafenib plus trametinib with dabrafenib alone,19 these findings provide clear evidence of the benefit of combined MEK and BRAF inhibition. The data combining BRAF
A study proposed by Mingfeng Zhang, Xuehong Zhang, Abrar A. Qureshi, A. Heather Eliassen, Susan E. Hankinson, Jiali Han, hypothesizes the number of cutaneous nevi may reflect plasma hormone levels and predict breast cancer risk independently of previously known factors. read: “In summary, we identified the number of cutaneous nevi as a novel phenotypic marker
The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent protein kinase A (PKA)-dependent manner. PKA directly phosphorylates ataxia telangiectasia and Rad3-related protein (ATR) at Ser435, which actively
Increasingly important is the control of nevi in children, the incidence of melanoma in children is on the rise; the causes are debated, it seems that the exposure of children to sunlight during the middle of the day can play an important role. Those with fair skin, blonde or red hair, freckles, the inability to
