Higher coffee intake and decrease melanoma risk

Higher coffee intake and decrease melanoma risk

A study published by Oxford University press reveals that higher coffee intake was associated with a modest decrease in risk of melanoma;  the highest category of coffee intake was inversely associated with malignant melanoma. This association was statistically significant for caffeinated but not for decaffeinated coffee Coffee Drinking and Cutaneous Melanoma Risk in the NIH-AARP

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent protein kinase A (PKA)-dependent manner. PKA directly phosphorylates ataxia telangiectasia and Rad3-related protein (ATR) at Ser435, which actively

Sentinel node biopsy can predict melanoma progression

Sentinel node biopsy can predict melanoma progression

A study published on Cancer Research announces that sentinel node act as pivotal sites for determining progression patterns, revealing that the presence of CD30+ lymphocytes at those sites associate positively with melanoma progression. Read the abstract ! Vallacchi V, Vergani E, Camisaschi C, et al. Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome

Melanoma

Ulceration, Breslow thickness and Clark level significantly predicted sentinel lymph node disease in patients with thin melanomas

Breslow thickness ≥ 0.75 mm, Clark level ≥ IV, and ulceration significantly predict SLN disease in thin melanoma. Most SLN metastases (86.2%) occur in melanomas ≥ 0.75 mm, with 6.3% of these patients having SLN disease, whereas in melanomas < 0.75 mm, SLN metastasis rates are < 5%. By using a 5% metastasis risk threshold,

Lentigo Maligna Melanoma

A new study at Moffitt Cancer Center could offer hope to people with melanoma

Abstract from PLOS ONE: Intralesional Injection of Rose Bengal Induces a Systemic Tumor-Specific Immune Response in Murine Models of Melanoma and Breast Cancer  Paul Toomey,  Krithika Kodumudi, Amy Weber, Lisa Kuhn,  Ellen Moore, Amod A. Sarnaik, Shari Pilon-Thomas  Intralesional (IL) injection of PV-10 has shown to induce regression of both injected and non-injected lesions in patients with melanoma. To determine